Columba Bush (born August 17, 1953) is a Mexican-born American philanthropist. She is the wife of former Florida Governor Jeb Bush.
Bush has been active in promoting the arts. In 1999 she worked with Arts for a Complete Education/Florida Alliance for Arts Education (ACE/FAAE) to develop Arts for Life!, a program devoted to increasing the importance of art in the education system. She has also used her experience with her family's substance abuse issues to aid treatment and prevention programs such as the National Institute on Alcohol Abuse and Alcoholism (NIAAA). She has served as co-chair of the NIAAA initiative, Leadership to Keep Children Alcohol Free, and has served on the board of the Center on Addiction and Substance Abuse at Columbia University.